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Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China. State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. Electronic address: chenjg@pku.edu.cn.

Pharmacological research. 2015;:11-5
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Abstract

Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.

Methodological quality

Publication Type : Review

Metadata

MeSH terms : Antineoplastic Agents